Heart rate increase on GLP-1 — November 2025

PeptideChemSF said:

Senior perspective on cardiovascular risk: I'm 70 years old and started this journey skeptically.

Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 → elevated homocysteine → increased cardiovascular risk marker.

The connection: B12 is a cofactor for homocysteine metabolism. Without adequate B12, homocysteine accumulates. This is ironic — taking a CV-protective medication while developing a CV risk factor from reduced nutrition.

Solution: comprehensive vitamin supplementation and regular lab monitoring. Don't let the medication's benefits be undermined by nutritional deficiencies.

PeptideChemSF said:

Senior perspective on cardiovascular risk: I'm 70 years old and started this journey skeptically.

PeptideChemSF said:

...we don't know the long-term effects of cardiovascular risk...

This is a fair point, and I think intellectual honesty requires acknowledging it. GLP-1 agonists in their current form have ~8-10 years of human exposure data. That's not nothing, but it's not 30+ years either.

However: the risk-benefit calculation should also consider the KNOWN long-term effects of untreated obesity — diabetes, cardiovascular disease, cancer, joint destruction, reduced lifespan by 5-10 years.

Uncertainty about GLP-1 long-term safety vs certainty about obesity consequences. The calculus seems clear to me, but reasonable people can disagree.

PeptideChemSF said:

Senior perspective on cardiovascular risk: I'm 70 years old and started this journey skeptically.

This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.

Adding the clinical framing, because it changes how the question reads.

Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my key markers:

Weight: consistent downtrend, -1.6 lbs/week average
Fasting glucose (finger stick): stable at 83 mg/dL
Blood pressure (home): 116/73 average
Resting heart rate: 63 bpm (down from 79)
Waist circumference: down 13 inches total

The resting heart rate improvement correlates with cardiovascular fitness gains. Everything is moving in the right direction.

mark_tokyo said:

PeptideChemSF said: ...we don't know the long-term effects of cardiovascular risk...

6 month update on cardiovascular risk: down 56 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.