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ForumsCardiovascular OutcomesApoB reduction on tirzepatide — looking for input Page 3

ApoB reduction on tirzepatide — looking for input

TomTeleRx Tue, Jul 9, 2024 at 9:38 AM 34 replies 2,140 viewsPage 3 of 7
patPC_UT
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Jul 10, 2024 at 12:25 PM#11
sophie_paris said:
The GIP arm is doing real work rather than padding the label.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

Last edited: Jul 10, 2024 at 5:25 PM
23 21sarah_nash92, FitDadDave, RunnerRach and 20 others
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DebRD_ATL
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Jul 10, 2024 at 3:07 PM#12

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

24 22RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 21 others
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Dr.CardioMD
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Jul 10, 2024 at 5:49 PM#13
GenomicsKate said:
ApoB is the more informative number and it is cheap.

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

25 23tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 22 others
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DanielChem_CHI
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Jul 10, 2024 at 8:31 PM#14

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

26 24ben_calgary, patPC_UT, Dr.DermMIA and 23 others
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mike_mod
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Jul 10, 2024 at 11:13 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Thread quality here is what the rules are for. Keep it up.

27 0PurityPaulOR, MaxMetOK, MounjBrad and 24 others
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