SarahChen_PharmD said:Relative and absolute effects need reading together.
6 month update on cardiovascular risk: down 45 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
pam_columbus said:Agreed, and subgroup analyses deserve particular suspicion.
Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.
SarahChen_PharmD said:Relative and absolute effects need reading together.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.
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View ResultsAdmin said:My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
Dizziness and cardiovascular risk: I was lightheaded for the first 2 weeks. Root cause was a combination of reduced caloric intake and mild dehydration.
Fix: minimum 80-100oz water daily, don't skip meals even if you're not hungry (eat small protein-rich snacks), and stand up slowly from sitting/lying positions. Also check your blood pressure — GLP-1-induced weight loss can make BP meds too strong, requiring dose reduction.