Peptide oxidation and deamidation — November 2025

Dr.ObesityMed said:

It is worth asking what the claim would look like if it were false.

There is a second half to this that has not been said yet. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

Dr.PeteFamMed said:

Say what you would expect to see if you were wrong, before you look.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

Dr.PeteFamMed said:

Say what you would expect to see if you were wrong, before you look.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.