GLP-1 receptor expression in cardiac tissue — 6 month update

sean_dublin said:

Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

This is exactly what I could not find anywhere else. I will report back once I have actually tried it.

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Happy to go further on any of that.

Dr.ObesityLA said:

PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

I would rather be corrected than agreed with, if it comes to it.

One concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.