GLP-1 and arterial inflammation — March 2026

laura_annarbor said:

My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.

Senior perspective on cardiovascular risk: I'm 71 years old and started this journey skeptically. My geriatrician recommended it after years of failed interventions.

13 months later: down 49 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.

To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.

Dr.BariatricHTX said:

Senior perspective on cardiovascular risk: I'm 71 years old and started this journey skeptically.

Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 → elevated homocysteine → increased cardiovascular risk marker.

The connection: B12 is a cofactor for homocysteine metabolism. Without adequate B12, homocysteine accumulates. This is ironic — taking a CV-protective medication while developing a CV risk factor from reduced nutrition.

Solution: comprehensive vitamin supplementation and regular lab monitoring. Don't let the medication's benefits be undermined by nutritional deficiencies.

laura_annarbor said:

My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.

Second this.

Clinical perspective, offered as context rather than as advice.

laura_annarbor said:

...we're creating a generation dependent on cardiovascular risk...

I understand the concern, but consider this analogy: are we "creating a generation dependent on" blood pressure medication? Cholesterol medication? Thyroid medication?

Obesity is a chronic disease with biological drivers. Treating it with medication is no different from treating any other chronic condition. The "dependency" framing implies weakness or moral failure — neither of which is accurate.

If ongoing medication is what keeps someone healthy, that's successful treatment, not dependency.