Dr.RaviCardio said:For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and…
That reframing is the part I needed.
Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
VendorMark said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
This is my experience too, for whatever a second data point is worth. Posting only so the count is not one.
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View ResultsVendorMark said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
There is a second half to this that has not been said yet. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.
Reporting back.
Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me. I was escalating because the number was available, not because I had stopped responding.