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ForumsCardiovascular OutcomesNNT for MACE prevention — semaglutide vs statin vs SGLT2i comparison Page 6

NNT for MACE prevention — semaglutide vs statin vs SGLT2i comparison

BiostatsBrad Tue, May 19, 2026 at 12:55 AM 26 replies 690 viewsPage 6 of 6
tom_AK
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Jan 2026
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May 31, 2026 at 11:30 PM#26

A narrower follow-up, since the general answer is now clear:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

Last edited: Jun 1, 2026 at 3:30 AM
11 11steve_okc, dave_SLC, FDA_TrackerJim and 8 others
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mike.trainer_LA
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Apr 2024
Los Angeles, CA
Jun 2, 2026 at 1:35 PM#27
jason_paloalto said:
One habit that pays for itself: post the method alongside the number.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

10 10newstart_MO, mia_MS2, LeilaHI and 7 others
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sarah_TO
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Toronto, CA
Jun 4, 2026 at 3:40 AM#28
jason_paloalto said:
One habit that pays for itself: post the method alongside the number.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

Worth separating that from cardiovascular outcomes, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

9 9GraceAZ_72, carl_compliance, DanielChem_CHI and 6 others
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PharmD_Rodriguez
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Miami, FL
Jun 5, 2026 at 5:43 PM#29
jason_paloalto said:
One habit that pays for itself: post the method alongside the number.

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

8 8dan_philly, MeganSA_TX, LarryQC_SD and 5 others
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BiostatsBrad
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Jul 2024
Durham, NC
Jun 7, 2026 at 7:45 AM#30

OP back with an update, since a thread like this is useless without one.

Update. I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks. Worth knowing rather than worth repeating.

Last edited: Jun 7, 2026 at 8:45 AM
36 11NicoleRaleigh, james_edin, FranDenver and 33 others
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