Oral semaglutide bioavailability optimization — 12 month update

GenomicsKate said:

The version of this that has an answer is narrower than the version being asked.

Adding the part of the answer the thread has not reached. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

A narrower follow-up, since the general answer is now clear:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

Dr.NateNeph said:

Keep the original post as written when you update it, and add the correction underneath.

Pushing back on Dr.NateNeph here. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

I would rather be corrected than agreed with, if it comes to it.

Dr.NateNeph said:

Keep the original post as written when you update it, and add the correction underneath.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.