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ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — any impact on this risk factor? Page 2

Lp(a) on GLP-1 agonists — any impact on this risk factor?

LipidDoc_ATL Sun, Jun 7, 2026 at 7:49 AM 8 replies 202 viewsPage 2 of 2
LarryQC_SD
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Jan 2024
San Diego, CA
Jun 7, 2026 at 9:03 AM#6
BethLabQueen said:
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data: Category Marker Before After…

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

Last edited: Jun 7, 2026 at 10:03 AM
32 2NurseKim_ATL, paul_denver, TinaHashiRN and 29 others
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Dr.PeteFamMed
Senior Member
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Jan 2024
Minneapolis, MN
Jun 7, 2026 at 9:31 AM#7
LipidDoc_ATL said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1586986Particle count (more precise than LDL-C)
Small dense LDL61%30%Atherogenic pattern
Remnant cholesterol3815Triglyceride-rich lipoproteins
oxLDL7144Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

31 1tommy_boulder, hyun_seoul, jim_asheville and 28 others
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Dr.KarenChen
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San Francisco, CA
Jun 7, 2026 at 9:59 AM#8
LarryQC_SD said:
Careful with treating an unchanged LDL-C as a failure.

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.4% to 7.9% over 9 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

30 0TomFromTexas, mike.trainer_LA, sarah_nash92 and 27 others
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tom_AK
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Jan 2026
Anchorage, AK
Jun 7, 2026 at 10:27 AM#9

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

29 24jennifer_SEA, tyler_CSCS, VanRx_Mike and 26 others
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LipidDoc_ATL
Senior Member
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Apr 2024
Atlanta, GA
Jun 7, 2026 at 12:41 PM#10

OP back with an update, since a thread like this is useless without one.

Closing this out. What actually changed my mind was the point about waiting for a trend instead of reading a single measurement, which is embarrassing in hindsight and worth saying anyway.

Last edited: Jun 7, 2026 at 5:41 PM
19 19KristenIndy, MarkLI_maint, Dr.PeteFamMed and 16 others
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