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ForumsPsychological & BehavioralCognitive effects of GLP-1 agonists — my results so far

Cognitive effects of GLP-1 agonists — my results so far

Admin Sun, Mar 15, 2026 at 12:20 AM 20 replies 856 viewsPage 1 of 4
Admin
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Mar 15, 2026 at 12:20 AM#1

My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer have my main coping mechanism.

What would genuinely help is knowing how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Numbers rather than impressions, if you have them.

26 21PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 23 others
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labquiet_amy
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Mar 15, 2026 at 1:38 AM#2
Admin said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…
Admin said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

25 20HPLC_Greg, LibrarianMeg, bri_stats and 22 others
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KetoKyle
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Mar 15, 2026 at 2:56 AM#3
labquiet_amy said:
Admin said: ...mental health should only be used alongside therapy...

Body image adjustment with mental health: I've lost 84 lbs but when I look in the mirror, I still see my old self sometimes. "Phantom fat" is a real phenomenon.

My therapist specializes in body image issues with weight loss patients. She says it can take 12-18 months for your brain's body map to update. In the meantime: take progress photos (your eyes lie but cameras don't), try on old clothes, and be patient with yourself.

24 19pat_auckland, Dr.GastroMayo, JakeBK_lifts and 21 others
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patPC_UT
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Mar 15, 2026 at 4:14 AM#4
Admin said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Same experience, arrived at from the opposite direction. I had assumed I was the exception until I read this.

23 18JessicaM_2024, TomFromTexas, mike.trainer_LA and 20 others
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hyun_seoul
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Mar 15, 2026 at 11:46 AM#5

From the other side of the consultation, briefly.

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
22 17LipidDoc_ATL, BariatricNurseD, MASHdoc_SA and 19 others
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