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ForumsPsychological & BehavioralCognitive effects of GLP-1 agonists — my results so far Page 2

Cognitive effects of GLP-1 agonists — my results so far

Admin Sun, Mar 15, 2026 at 12:20 AM 20 replies 856 viewsPage 2 of 4
Dr.NateNeph
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Mar 15, 2026 at 7:18 PM#6
labquiet_amy said:
Admin said: ...mental health should only be used alongside therapy...

Pushing back on labquiet_amy here. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

I would rather be corrected than agreed with, if it comes to it.

21 16JakeSmashed95, NauseaFreeNow, SteveThurs and 18 others
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SleepDoc_PDX
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Mar 16, 2026 at 2:50 AM#7
Admin said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 3. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

20 15hank_denver, carlos_SATX, sophie_paris and 17 others
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LipidDoc_ATL
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Mar 16, 2026 at 10:23 AM#8
Dr.NateNeph said:
I would be careful about how confidently the flatness reports get attributed.

Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming a new version of yourself.

Key realizations: I used food to manage emotions, I had internalized fatphobia that I'm still unpacking, my social identity was partly built around being "the big guy/girl," and learning to accept compliments is surprisingly hard when you've been invisible for years.

Physical transformation without emotional processing is unstable. Do both.

19 14AttorneyGrant, DebRD_ATL, KristenIndy and 16 others
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adam_van
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Mar 16, 2026 at 5:56 PM#9

One thing that is still open after KetoKyle’s answer:

Was that from a primary source or from a summary of one?

18 13tommy_boulder, hyun_seoul, jim_asheville and 15 others
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Admin
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Mar 18, 2026 at 6:10 AM#10

OP back with an update, since a thread like this is useless without one.

Update: I got the sleep and the intake sorted before deciding it was the drug, and most of the flatness went with them. Not all of it, and I am watching the rest.

Last edited: Mar 18, 2026 at 10:10 AM
20 18PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 17 others
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