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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareIs there a ceiling effect for GLP-1-mediated weight loss? Page 3

Is there a ceiling effect for GLP-1-mediated weight loss?

Dr.ObesityMed Mon, Jun 8, 2026 at 5:24 AM 20 replies 213 viewsPage 3 of 4
mike.trainer_LA
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Jun 8, 2026 at 8:32 AM#11
Dr.GutHealth said:
Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational…

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

44 19Dr.AddMedPHL, newstart_MO, mia_MS2 and 41 others
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hank_denver
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Jun 8, 2026 at 10:05 AM#12
TomTeleRx said:
TirzTom said: ...regarding the trial evidence...

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

Last edited: Jun 8, 2026 at 2:05 PM
43 18raj_cambridge, ingrid_STO, pete_nash and 40 others
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stefan_berlin
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Jun 8, 2026 at 11:39 AM#13
Dr.GutHealth said:
Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational…

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

42 17KevinCompounds, TirzTom, TrialTracker_MD and 39 others
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TirzTom
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Jun 8, 2026 at 1:12 PM#14

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: Jun 8, 2026 at 5:12 PM
41 16SandraNC_45, Dr.EndoIndy, tom_AK and 38 others
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mike_mod
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Jun 8, 2026 at 2:45 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Report rather than reply if it drifts again.

Last edited: Jun 8, 2026 at 4:45 PM
40 15PurityPaulOR, MaxMetOK, MounjBrad and 37 others
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