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ForumsOral GLP-1 AgonistsIs oral sema actually as effective as the injection version? — 12 month update Page 3

Is oral sema actually as effective as the injection version? — 12 month update

tommy_boulder Tue, Dec 16, 2025 at 3:17 AM 35 replies 1,548 viewsPage 3 of 7
DebRD_ATL
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Dec 17, 2025 at 2:24 PM#11
anna.melb_AU said:
It helps to say which part of this you are uncertain about.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

14 14BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 11 others
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dan_philly
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Dec 18, 2025 at 7:37 AM#12
VanRx_Mike said:
The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

13 13AmyNC_wife, SkepticalSean, Dr.CardioMD and 10 others
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PeptideChemSF
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Dec 19, 2025 at 12:51 AM#13
anna.melb_AU said:
It helps to say which part of this you are uncertain about.

This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

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Dr.PulmRoch
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Dec 19, 2025 at 6:05 PM#14

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: Dec 19, 2025 at 7:05 PM
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Admin
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Dec 20, 2025 at 11:19 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out.

Last edited: Dec 20, 2025 at 3:19 PM
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