quinn_sf said:Say what you would expect to see if you were wrong, before you look.
This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.
Adding the clinical framing, because it changes how the question reads. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.
That is the short version; the long version is somebody else's post.
Dr.LipidDallas said:Start from the measurement rather than the conclusion.
Same experience, arrived at from the opposite direction. The detail I would add is minor and it is already implied above.
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View ResultsDr.LipidDallas said:Start from the measurement rather than the conclusion.
Adding the part of the answer the thread has not reached. The pharmacokinetics explain nearly every practical question asked here. Albumin binding above 99% slows clearance enough to make weekly dosing possible; a terminal half-life near a week means four to five weeks to steady state and therefore a four-week titration interval; subcutaneous bioavailability around 89% means injection site barely matters. Those three facts answer most timing questions before they are asked.
One concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.