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ForumsPharmacology & MechanismsSemaglutide albumin binding and the C-18 fatty acid linker — 12 month update Page 5

Semaglutide albumin binding and the C-18 fatty acid linker — 12 month update

LindaRN_retired Wed, Feb 7, 2024 at 11:54 AM 31 replies 2,291 viewsPage 5 of 7
mona_PHX
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Feb 8, 2024 at 6:09 PM#21
Dr.NateNeph said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Feb 8, 2024 at 9:09 PM
44 19RetaRick_CA, JenPlateau, SallyK_inj and 41 others
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mel_PDX
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Feb 9, 2024 at 12:37 AM#22
Dr.NateNeph said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

43 18Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 40 others
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denise_HTX
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Feb 9, 2024 at 7:05 AM#23
Dr.NateNeph said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

42 17JessicaH_TX, KevinCompounds, TirzTom and 39 others
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JenPlateau
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Feb 9, 2024 at 1:33 PM#24

From the other side of the consultation, briefly. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

Last edited: Feb 9, 2024 at 7:33 PM
41 16FitDadDave, RunnerRach, TrialNerd_Beth and 38 others
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Dr.EndoIndy
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Feb 9, 2024 at 8:01 PM#25
JenPlateau said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Same pattern here, and in the same order. Posting only so the count is not one.

40 15SandraNC_45, Dr.EndoIndy, tom_AK and 37 others
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