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ForumsOral GLP-1 AgonistsDanuglipron dose optimization — 12 month update Page 5

Danuglipron dose optimization — 12 month update

Dr.MetabolicMD Sat, Mar 14, 2026 at 8:45 PM 34 replies 1,534 viewsPage 5 of 7
tommy_boulder
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Mar 27, 2026 at 1:54 AM#21
raj_cambridge said:
Say what you would expect to see if you were wrong, before you look.

Genuinely useful, thank you. I had the facts and not the framework. Adding it to my notes with a link back to this thread.

Last edited: Mar 27, 2026 at 2:54 AM
12 12paul_denver, TinaHashiRN, robert_kc and 9 others
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Dr.EndoIndy
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Mar 31, 2026 at 9:28 PM#22

From the other side of the consultation, briefly. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

11 11LeilaHI, marcus_mpls, DeniseRN_TPA and 8 others
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zoe_NC
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Apr 5, 2026 at 4:58 PM#23
Dr.EndoIndy said:
It helps to ask what evidence would change your mind before you look at any.

This matches mine closely enough to be worth saying so out loud. I had assumed I was the exception until I read this.

10 10james_edin, FranDenver, Dr.BariatricHTX and 7 others
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nancy_portland
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Apr 10, 2026 at 12:26 PM#24
Dr.EndoIndy said:
It helps to ask what evidence would change your mind before you look at any.

There is a second half to this that has not been said yet. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Last edited: Apr 10, 2026 at 1:26 PM
9 9Dr.PeteFamMed, claudia_zurich, nancy_portland and 6 others
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FDA_TrackerJim
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Apr 15, 2026 at 7:51 AM#25

Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Ask again with the specifics and you will get a better answer than this one.

8 8jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 5 others
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