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ForumsOral GLP-1 AgonistsDanuglipron dose optimization — 12 month update Page 3

Danuglipron dose optimization — 12 month update

Dr.MetabolicMD Sat, Mar 14, 2026 at 8:45 PM 34 replies 1,534 viewsPage 3 of 7
PurityPaulOR
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Mar 16, 2026 at 1:44 AM#11
NurseLeah_Nash said:
Worth answering the question that was asked rather than the one behind it.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Last edited: Mar 16, 2026 at 4:44 AM
43 18Dr.LeslieOBGYN, MikeNYC_runner and 40 others
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B12Beth
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Mar 17, 2026 at 4:13 AM#12
BariatricNurseD said:
The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes. Sending this to two other people who asked me the same thing last week.

42 17carl_compliance, DanielChem_CHI, marco_milano and 39 others
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tampaLisa73
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Mar 18, 2026 at 6:41 AM#13
NurseLeah_Nash said:
Worth answering the question that was asked rather than the one behind it.

I read this differently from NurseLeah_Nash, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

Last edited: Mar 18, 2026 at 7:41 AM
41 16sarah_nash92, FitDadDave, RunnerRach and 38 others
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DataDave
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Mar 19, 2026 at 9:09 AM#14

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

40 15amsterdam_pete, LondonLisa, mike_nyc and 37 others
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Admin
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Mar 20, 2026 at 11:36 AM#15

Moderator note: a couple of off-topic posts removed. Carry on.

39 14PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 36 others
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