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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOff-TopicNon-scale victories thread — what worked for you? Page 3

Non-scale victories thread — what worked for you?

anders_CPH Sat, Jul 12, 2025 at 8:57 AM 34 replies 1,522 viewsPage 3 of 7
CarlaRPh_TPA
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Jul 15, 2025 at 3:16 PM#11
julia.endo said:
Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation.
julia.endo said:
...regarding food noise mechanism of action...

To build on this — the mechanism is more complex than "it makes you less hungry." GLP-1 agonists:

  1. Activate hypothalamic satiety centers (appetite reduction)
  2. Delay gastric emptying (prolonged fullness)
  3. Potentiate glucose-dependent insulin secretion
  4. Suppress glucagon secretion
  5. Modulate reward pathway dopaminergic signaling
  6. Reduce hepatic lipogenesis
  7. Have direct cardiovascular protective effects

It's a multi-target drug with systemic metabolic effects. Understanding the mechanism helps us predict and manage side effects.

23 21FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 20 others
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chris_chi24
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Jul 16, 2025 at 9:02 PM#12
jennifer_SEA said:
The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related…

Genuinely useful, thank you. I had the facts and not the framework.

24 22MounjBrad, nick_newbie, DadBodDave and 21 others
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PharmHunterJen
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Jul 18, 2025 at 2:49 AM#13
julia.endo said:
Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

25 23kevin_tulsa, Dr.PainCLE, mike_mealprep and 22 others
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Dr.PulmRoch
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Jul 19, 2025 at 8:36 AM#14

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

26 24DebRD_ATL, KristenIndy, MarkLI_maint and 23 others
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mike_mod
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Jul 20, 2025 at 2:24 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.

27 0PurityPaulOR, MaxMetOK, MounjBrad and 24 others
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