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ForumsPharmacology & MechanismsHas anyone dealt with molecular dynamics simulations of glp-1r binding? Page 8

Has anyone dealt with molecular dynamics simulations of glp-1r binding?

BrianDallas92 Wed, Apr 16, 2025 at 2:37 AM 36 replies 1,942 viewsPage 8 of 8
JennaRN
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Nov 18, 2025 at 7:26 AM#36
Dr.AddMedPHL said:
Say what you would expect to see if you were wrong, before you look.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Last edited: Nov 18, 2025 at 8:26 AM
7 5Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 4 others
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chris_chi24
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Nov 30, 2025 at 1:31 PM#37
Dr.AddMedPHL said:
Say what you would expect to see if you were wrong, before you look.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Last edited: Nov 30, 2025 at 4:31 PM
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andrew_nyc
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Dec 12, 2025 at 7:29 PM#38
Dr.AddMedPHL said:
Say what you would expect to see if you were wrong, before you look.

That reframing is the part I needed. Printing the relevant bit and taking it with me.

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Dr.NateNeph
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Dec 25, 2025 at 1:20 AM#39

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

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NurseKim_ATL
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Jan 6, 2026 at 7:04 AM#40
Dr.NateNeph said:
The mechanism and the magnitude are separate questions.

This is my experience too, for whatever a second data point is worth.

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