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ForumsPharmacology & MechanismsReceptor internalization and recycling — anyone have experience? Page 7

Receptor internalization and recycling — anyone have experience?

jennifer_SEA Sat, Apr 26, 2025 at 6:12 AM 36 replies 2,034 viewsPage 7 of 8
B12Beth
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May 10, 2025 at 1:08 PM#31

One thing that is still open after Dr.NutriCornell’s answer:

How would you tell the difference between that and the alternative explanation?

Last edited: May 10, 2025 at 4:08 PM
18 16GraceAZ_72, carl_compliance, DanielChem_CHI and 15 others
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Dr.ObesityMed
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May 11, 2025 at 2:34 PM#32
jennifer_SEA said:
Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

19 17PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 16 others
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LeilaHI
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May 12, 2025 at 3:59 PM#33
jennifer_SEA said:
Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

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JakeSmashed95
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May 13, 2025 at 5:24 PM#34
jennifer_SEA said:
Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

21 19Dr.LipidDallas, alex_tucson, kevin_tulsa and 18 others
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LindaRN_retired
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May 14, 2025 at 6:48 PM#35

From the other side of the consultation, briefly. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

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