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ForumsPharmacology & MechanismsReceptor internalization and recycling — anyone have experience? Page 6

Receptor internalization and recycling — anyone have experience?

jennifer_SEA Sat, Apr 26, 2025 at 6:12 AM 36 replies 2,034 viewsPage 6 of 8
RickReta_CO
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May 5, 2025 at 4:57 AM#26
TrialTracker_MD said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.

Last edited: May 5, 2025 at 9:57 AM
42 15matt_MKE, Dr.ReproEndo, lucas_SP_BR and 39 others
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Dr.NutriCornell
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May 6, 2025 at 6:39 AM#27

Clinical perspective, offered as context rather than as advice. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

I would rather be corrected than agreed with, if it comes to it.

43 16Dr.SleepRoch, laura_annarbor, JenMemphis and 40 others
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denise_HTX
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May 7, 2025 at 8:20 AM#28
Dr.NutriCornell said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Same experience, arrived at from the opposite direction.

Last edited: May 7, 2025 at 10:20 AM
44 17JessicaH_TX, KevinCompounds, TirzTom and 41 others
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lisa_labSD
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May 8, 2025 at 10:01 AM#29
Dr.NutriCornell said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Coming at Dr.NutriCornell’s question from a different direction. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

45 18lori_vegas, Dr.PulmRoch, maya_sedona and 42 others
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jennifer_SEA
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May 9, 2025 at 11:41 AM#30

Closing the loop on my own question.

Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

17 15hyun_seoul, jim_asheville, matt_MKE and 14 others
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