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ForumsMetabolic Health & DiabetesGLP-1 and gluconeogenesis — what worked for you? Page 3

GLP-1 and gluconeogenesis — what worked for you?

matt_MKE Mon, Oct 20, 2025 at 10:35 AM 50 replies 1,666 viewsPage 3 of 10
mike_nyc
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Oct 23, 2025 at 12:40 AM#11
sean_dublin said:
My labs after 9 months on glycaemic control: A1C 5.9%, fasting glucose 89 mg/dL, fasting insulin 4 uIU/mL.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

29 2maya_sedona, stefan_berlin, Dr.EM_Chicago and 26 others
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MarkLI_maint
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Oct 24, 2025 at 2:41 PM#12
JessicaH_TX said:
PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

Bookmarking. The distinction being drawn above is the one nobody else makes.

30 3TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 27 others
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emily_PDX
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Oct 26, 2025 at 4:40 AM#13
sean_dublin said:
My labs after 9 months on glycaemic control: A1C 5.9%, fasting glucose 89 mg/dL, fasting insulin 4 uIU/mL.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

31 4Dr.NateNeph, PharmD_Rodriguez, julia.endo and 28 others
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dan_philly
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Oct 27, 2025 at 6:40 PM#14

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Oct 27, 2025 at 9:40 PM
32 5Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 29 others
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mike_mod
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Oct 29, 2025 at 8:38 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Thread quality here is what the rules are for. Keep it up.

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