Why does it stop working after a while for some people — anyone have experience?

claudia_zurich said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Adding the part of the answer the thread has not reached. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Following on from claudia_zurich — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

TrialTracker_MD said:

If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

TrialTracker_MD said:

If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.