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ForumsPharmacology & MechanismsWhy does it stop working after a while for some people — anyone have experience? Page 3

Why does it stop working after a while for some people — anyone have experience?

kim_atl_prep Thu, Sep 18, 2025 at 5:27 PM 38 replies 2,109 viewsPage 3 of 8
Dr.BariatricHTX
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Sep 20, 2025 at 1:17 AM#11
pat_auckland said:
PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

18 16CarlaRPh_TPA, steph_laguna, fiona_glasgow and 15 others
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pam_columbus
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Sep 20, 2025 at 6:07 AM#12
nancy_portland said:
The pharmacokinetics explain nearly every practical question asked here.

Genuinely useful, thank you. I had the facts and not the framework.

19 17alex_tucson, kevin_tulsa, Dr.PainCLE and 16 others
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TinaHashiRN
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Sep 20, 2025 at 10:56 AM#13
pat_auckland said:
PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

I read this differently from pat_auckland, on substance rather than tone. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

20 18Dr.Martinez, mike_mod, SarahChen_PharmD and 17 others
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dan_philly
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Sep 20, 2025 at 3:45 PM#14

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

21 19Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 18 others
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mike_mod
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Sep 20, 2025 at 8:34 PM#15

Moderator note: a couple of off-topic posts removed.

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