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ForumsDosing & ProtocolsInsulin syringe unit conversion for compounded sema — 12 month update Page 4

Insulin syringe unit conversion for compounded sema — 12 month update

BrianDallas92 Tue, Dec 17, 2024 at 3:18 AM 34 replies 1,924 viewsPage 4 of 7
PedsEndoPhilly
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Dec 29, 2024 at 11:21 PM#16

From the other side of the consultation, briefly.

Bacteriostatic water quality matters for dosing arithmetic reconstitution. Not all BAC water is created equal:

  • Should contain 0.9% benzyl alcohol as preservative
  • Must be sterile and pyrogen-free
  • Should come in a sealed, intact vial
  • Check expiration date — yes, BAC water expires
  • Store at room temperature, protected from light

I buy from a reputable medical supply company, not Amazon marketplace sellers. The $3 savings isn't worth the infection risk from unverified BAC water.

46 19sarah_TO, wendy_avl, jason_paloalto and 43 others
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JakeSmashed95
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Jan 1, 2025 at 1:53 AM#17
PedsEndoPhilly said:
Bacteriostatic water quality matters for dosing arithmetic reconstitution.

Sharing my dosing arithmetic titration experience with compounded semaglutide — I have been tracking injection volumes meticulously:

Using 5mg/2mL concentration with 1cc insulin syringes:

  • Month 1: 10 units (0.25mg) — mild appetite reduction
  • Month 2: 20 units (0.5mg) — significant appetite suppression
  • Month 3: 30 units (0.75mg) — custom intermediate dose
  • Month 4: 40 units (1.0mg) — optimal for me, staying here

The beauty of compounded vials is you can do custom intermediate doses. My provider was great about tailoring to my response.

47 20kevin_tulsa, Dr.PainCLE, mike_mealprep and 44 others
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dan_philly
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Jan 3, 2025 at 4:24 AM#18
PedsEndoPhilly said:
Bacteriostatic water quality matters for dosing arithmetic reconstitution.

PedsEndoPhilly has the substance of this right. The condition it depends on is worth stating. Worth adding the genuine exception, because it is real and narrow: a change made for an identified patient where the prescriber determines it produces a significant clinical difference for that patient. A grid of fixed doses offered to everybody is not that, whatever the intake form says.

48 21SkepticalSean, Dr.CardioMD, EndoResFellow and 45 others
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cory_ATX
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Jan 5, 2025 at 6:54 AM#19
PedsEndoPhilly said:
Bacteriostatic water quality matters for dosing arithmetic reconstitution.

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

49 22Dr.PathRoch, mona_PHX, andrew_nyc and 46 others
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mike_mod
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Jan 7, 2025 at 9:23 AM#20

Moderator note: a couple of off-topic posts removed.

21 19PurityPaulOR, MaxMetOK, MounjBrad and 18 others
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