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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 7

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 7 of 8
rachel_ABQ
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Mar 22, 2026 at 3:55 AM#31

Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

18 16nick_newbie, DadBodDave, AmyNC_wife and 15 others
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AttorneyGrant
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Mar 29, 2026 at 9:05 AM#32
rachel_ABQ said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

This matches mine closely enough to be worth saying so out loud.

19 17laura_annarbor, JenMemphis, pat_auckland and 16 others
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JennaRN
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Apr 5, 2026 at 2:10 PM#33
rachel_ABQ said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

There is a second half to this that has not been said yet. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

That is the short version; the long version is somebody else's post.

20 18BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 17 others
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BethLabQueen
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Apr 12, 2026 at 7:12 PM#34

Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

21 19cory_ATX, lori_vegas, Dr.PulmRoch and 18 others
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jason_sac26
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Apr 20, 2026 at 12:09 AM#35

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

Last edited: Apr 20, 2026 at 2:09 AM
22 20Dr.PulmRoch, maya_sedona, stefan_berlin and 19 others
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