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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 6

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 6 of 8
anders_CPH
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Feb 13, 2026 at 7:11 PM#26

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

42 15CryptoCarl, MariaRD, AussieAnna and 39 others
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paul_denver
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Feb 21, 2026 at 2:10 AM#27

One thing that is still open after TinaHashiRN’s answer:

Was that from a primary source or from a summary of one?

Last edited: Feb 21, 2026 at 8:10 AM
43 16jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 40 others
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CryptoCarl
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Feb 28, 2026 at 9:05 AM#28
anders_CPH said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

44 17AussieAnna, BethLabQueen, ChrisMacros and 41 others
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Dr.LipidDallas
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Mar 7, 2026 at 3:55 PM#29
anders_CPH said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

45 18lori_vegas, Dr.PulmRoch, maya_sedona and 42 others
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FranDenver
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Mar 14, 2026 at 10:42 PM#30

Closing the loop on my own question.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.

17 15GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 14 others
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