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ForumsPharmacology & MechanismsGLP-1R allosteric modulators — 12 month update Page 4

GLP-1R allosteric modulators — 12 month update

InsuranceTom Sun, Mar 15, 2026 at 3:41 PM 18 replies 814 viewsPage 4 of 4
Dr.GutHealth
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Mar 20, 2026 at 6:48 PM#16

Adding the clinical framing, because it changes how the question reads. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

20 20VanRx_Mike, steve_okc, dave_SLC and 17 others
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josh_phd_bmore
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Mar 21, 2026 at 12:24 PM#17

Adding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

19 19Dr.ObesityLA, NurseKim_ATL, paul_denver and 16 others
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COA_Karl
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Mar 22, 2026 at 5:59 AM#18

One thing that is still open after Dr.RaviCardio’s answer:

Was that from a primary source or from a summary of one?

Last edited: Mar 22, 2026 at 6:59 AM
18 18hyun_seoul, jim_asheville, matt_MKE and 15 others
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RunnerRach
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Mar 22, 2026 at 11:34 PM#19
josh_phd_bmore said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

I would rather be corrected than agreed with, if it comes to it.

17 17jennifer_SEA, tyler_CSCS, VanRx_Mike and 14 others
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mike_mod
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Mar 23, 2026 at 5:09 PM#20

Moderator note: a couple of off-topic posts removed. No action needed from anybody.

45 20PurityPaulOR, MaxMetOK, MounjBrad and 42 others
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