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ForumsPharmacology & MechanismsSemaglutide albumin binding and the C-18 fatty acid linker — anyone have experience? Page 6

Semaglutide albumin binding and the C-18 fatty acid linker — anyone have experience?

cory_ATX Fri, May 1, 2026 at 1:07 AM 27 replies 1,145 viewsPage 6 of 6
quinn_sf
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May 9, 2026 at 1:51 AM#26
james_edin said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

There is a second half to this that has not been said yet. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

49 24tane_welly, Dr.PathRoch, mona_PHX and 46 others
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PharmacoVig_BOS
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May 9, 2026 at 7:34 PM#27

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Last edited: May 9, 2026 at 10:34 PM
48 23Dr.GutHealth, amsterdam_pete, LondonLisa and 45 others
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paul_denver
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May 10, 2026 at 1:16 PM#28

Following on from james_edin — and this may be the naive question:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

47 22wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 44 others
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TomTeleRx
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May 11, 2026 at 6:58 AM#29
PharmacoVig_BOS said:
Practical: whatever you change, write down the date and the reason.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

46 21HPLC_Greg, LibrarianMeg, bri_stats and 43 others
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cory_ATX
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May 12, 2026 at 12:39 AM#30

Closing the loop on my own question.

Following this thread I went back and re-read the extension data properly. The point about trough rather than peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

Last edited: May 12, 2026 at 2:39 AM
24 24tane_welly, Dr.PathRoch, mona_PHX and 21 others
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