From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
Dr.NephBHM_UK said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.
Dr.NephBHM_UK said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
Adding the part of the answer the thread has not reached. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".
Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
Happy to go further on any of that.
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View ResultsAdding the numbers, since they settle part of this. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.
Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.