🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsGLP-1R desensitization — β-arrestin-mediated internalization Page 4

GLP-1R desensitization — β-arrestin-mediated internalization

NeuroNate Mon, Jun 8, 2026 at 3:41 AM 18 replies 396 viewsPage 4 of 4
pete_RVA
Member
178
890
Dec 2024
Richmond, VA
Jun 8, 2026 at 8:58 PM#16
paige_pharma said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Same experience, arrived at from the opposite direction. Nothing to add that would improve it.

1 24mike_mod
Reply Quote Save Share Report
KarenAZ_mom
Member
567
2,567
Aug 2024
Scottsdale, AZ
Jun 8, 2026 at 9:19 PM#17

Following on from PharmD_Rodriguez — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

2 0pete_manc_UK, anna.melb_AU
Reply Quote Save Share Report
Dr.PainCLE
Senior Member
1,234
6,234
Mar 2024
Cleveland, OH
Jun 8, 2026 at 9:40 PM#18
Dr.AddMedPHL said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

3 1oliver_london, tane_welly, Dr.PathRoch
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
JakeBK_lifts
Member
523
2,345
Jul 2024
Brooklyn, NY
Jun 8, 2026 at 10:01 PM#19
Dr.AddMedPHL said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.

4 2kate.chem, DataDave, Dr.GutHealth and 1 other
Reply Quote Save Share Report
Admin
Administrator
2,456
9,812
Oct 2023
Online
Jun 8, 2026 at 10:22 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

Last edited: Jun 9, 2026 at 2:22 AM
26 24PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 23 others
Reply Quote Save Share Report

Similar Threads

Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance13 replies
Semaglutide albumin binding and the C-18 fatty acid linker17 replies
GIP receptor pharmacology — why GIP agonism enhances GLP-113 replies
Glucagon receptor signaling — hepatic glycogenolysis and lipolysis16 replies
Structure-activity relationships of GLP-1 analogs12 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register