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ForumsPharmacology & MechanismsGLP-1R desensitization — β-arrestin-mediated internalization Page 3

GLP-1R desensitization — β-arrestin-mediated internalization

NeuroNate Mon, Jun 8, 2026 at 3:41 AM 18 replies 396 viewsPage 3 of 4
rachel_ABQ
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Jun 8, 2026 at 7:13 PM#11
DebRD_ATL said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

46 19nick_newbie, DadBodDave, AmyNC_wife and 43 others
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paige_pharma
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Jun 8, 2026 at 7:34 PM#12

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

That is the short version; the long version is somebody else's post.

47 20Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 44 others
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PharmD_Rodriguez
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Jun 8, 2026 at 7:55 PM#13
Dr.NutriCornell said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

This is where I part company with the consensus forming above. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

48 21robert_kc, dan_philly, MeganSA_TX and 45 others
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Dr.AddMedPHL
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Jun 8, 2026 at 8:16 PM#14

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

49 22TomFromTexas, mike.trainer_LA, sarah_nash92 and 46 others
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mike_mod
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Jun 8, 2026 at 8:37 PM#15

Moderator note: a couple of off-topic posts removed.

Last edited: Jun 8, 2026 at 10:37 PM
50 23PurityPaulOR, MaxMetOK, MounjBrad and 47 others
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