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ForumsMarketplace & ListingsCheapest place to get sema right now? Price keeps going up

Cheapest place to get sema right now? Price keeps going up

mona_PHX Fri, May 29, 2026 at 6:28 AM 19 replies 368 viewsPage 1 of 4
mona_PHX
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Dec 2024
Phoenix, AZ
May 29, 2026 at 6:28 AM#1

The list price and the price I actually pay differ by a factor of six depending on which of four routes I use, and none of that is transparent from the outside.

What I am trying to establish is what actually works on a prior-authorisation denial, as opposed to the list of things that sound like they should work.

If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

21 16RetaRick_CA, JenPlateau, SallyK_inj and 18 others
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anders_CPH
Senior Member
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7,234
Feb 2024
Copenhagen, DK
May 29, 2026 at 7:31 AM#2
mona_PHX said:
The list price and the price I actually pay differ by a factor of six depending on which of four routes I use, and none of that is transparent from…

My insurance denied my PA related to cost and coverage. Has anyone successfully appealed? I'm considering going compounded instead.

Last edited: May 29, 2026 at 11:31 AM
20 15MariaRD, AussieAnna, BethLabQueen and 17 others
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NauseaFreeNow
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Aug 2024
Indiana
May 29, 2026 at 8:34 AM#3
anders_CPH said:
My insurance denied my PA related to cost and coverage.
anders_CPH said:
...compounded vs brand cost and coverage...

This debate comes up weekly and I think both sides have valid points:

Pro-brand: FDA-approved, manufacturing standards guaranteed, clinical trial data directly applicable

Pro-compounded: 10x cost savings, same active molecule, independent testing available, accessibility

My position: if you can afford brand or have insurance coverage, that's the gold standard. If not, properly tested compounded from a 503B pharmacy is a reasonable alternative. Neither side should shame the other.

Last edited: May 29, 2026 at 12:34 PM
19 14Dr.PulmRoch, maya_sedona, stefan_berlin and 16 others
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MikeNYC_runner
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Jul 2024
New York, NY
May 29, 2026 at 9:37 AM#4
mona_PHX said:
The list price and the price I actually pay differ by a factor of six depending on which of four routes I use, and none of that is transparent from…

Mine went the same way, slower.

Last edited: May 29, 2026 at 11:37 AM
18 13GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 15 others
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Dr.NutriCornell
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Mar 2024
Ithaca, NY
May 29, 2026 at 3:47 PM#5

Adding the clinical framing, because it changes how the question reads.

Insurance update relevant to cost and coverage: I just got my prior auth approved through Cigna after 1 attempts.

What finally worked: a letter from my endocrinologist documenting BMI history (>3 years), failed diet attempts, comorbidities (PCOS + insulin resistance), and referencing the STEP trial data.

If your PA keeps getting denied, don't give up. Request a peer-to-peer review between your doctor and the insurance medical director. That's what finally broke through for me.

17 12pat_auckland, Dr.GastroMayo, JakeBK_lifts and 14 others
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