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ForumsVendor ReviewsI made a spreadsheet comparing vendor COAs — anyone have experience? Page 6

I made a spreadsheet comparing vendor COAs — anyone have experience?

JennaRN Fri, Mar 22, 2024 at 2:29 AM 36 replies 2,800 viewsPage 6 of 8
Dr.GastroMayo
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Apr 9, 2024 at 4:10 AM#26

Clinical perspective, offered as context rather than as advice. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

Last edited: Apr 9, 2024 at 9:10 AM
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CanadaChris
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Apr 11, 2024 at 5:48 AM#27
Dr.GastroMayo said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Second this.

Last edited: Apr 11, 2024 at 11:48 AM
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Dr.LipidDallas
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Apr 13, 2024 at 7:25 AM#28
Dr.GastroMayo said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

There is a second half to this that has not been said yet. They are not contradictory, they measure different things, and this is the single most common misreading of a certificate. Purity is a relative area measurement: the main peak as a percentage of total peak area in the chromatogram. Content is an absolute mass measurement against a reference standard. A vial can be 99% pure and contain 6.1mg — pure material, overfilled — or 99% pure and contain 3mg, which is pure material and a short fill. Purity tells you what fraction of what is there is the right molecule; content tells you how much of it there is. You need both, and a certificate with only purity is telling you half the story.

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kate.chem
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Apr 15, 2024 at 9:01 AM#29

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

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JennaRN
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Apr 17, 2024 at 10:35 AM#30

Reporting back.

Purity and content being different measurements was the piece I was missing. The vial was overfilled and pure, which is a very different problem from the one I thought I had.

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