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ForumsNutrition & SupplementationCreatine monohydrate + GLP-1 — looking for input Page 5

Creatine monohydrate + GLP-1 — looking for input

hyun_seoul Sun, Mar 15, 2026 at 10:11 AM 31 replies 1,267 viewsPage 5 of 7
tony_orlando
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Orlando, FL
Mar 16, 2026 at 11:51 PM#21
kate.chem said:
Regarding lean mass: I accidentally injected my dose intramuscularly instead of subcutaneously last week (went in at wrong angle, too deep).

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

32 5NauseaFreeNow, SteveThurs, B12Beth and 29 others
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traveltech_sara
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Jan 2025
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Mar 17, 2026 at 6:48 AM#22

Clinical perspective, offered as context rather than as advice.

Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the skeletal muscle fiber type distribution:

  • Decreased Type IIx (glycolytic, fast-twitch) fibers
  • Increased Type I (oxidative, slow-twitch) fibers
  • Improved mitochondrial density and function
  • Enhanced insulin-stimulated glucose uptake per fiber

This "metabolic remodeling" of muscle may contribute to improved insulin sensitivity independent of total lean mass changes. The muscle you keep becomes metabolically better, even if there's less of it[1].

References:
[1] Pirkmajer S, et al. Front Physiol. 2023;14:1123456.
33 6LarryQC_SD, wanda_boise, NurseAsh_DET and 30 others
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PharmHunterJen
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Mar 17, 2026 at 1:46 PM#23
traveltech_sara said:
Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…

Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.

Last edited: Mar 17, 2026 at 7:46 PM
34 7kevin_tulsa, Dr.PainCLE, mike_mealprep and 31 others
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rick_sfbay
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Mar 17, 2026 at 8:44 PM#24
traveltech_sara said:
Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…

Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months):

MetricBaselineMonth 3Month 6Month 9
Skeletal Muscle (lbs)69717273
Body Fat (lbs)101776145
Body Fat %41%32%26%20%
Visceral Fat (cm²)1661118656

Note: skeletal muscle mass dipped initially then recovered with consistent resistance training + high protein. The visceral fat reduction is where the metabolic magic happens.

35 8FranDenver, Dr.BariatricHTX, LindaRN_retired and 32 others
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VendorMark
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Mar 18, 2026 at 3:42 AM#25

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

36 9claudia_zurich, nancy_portland, rick_sfbay and 33 others
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