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ForumsNutrition & SupplementationCreatine monohydrate + GLP-1 — looking for input

Creatine monohydrate + GLP-1 — looking for input

hyun_seoul Sun, Mar 15, 2026 at 10:11 AM 31 replies 1,267 viewsPage 1 of 7
hyun_seoul
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Seoul, KR
Mar 15, 2026 at 10:11 AM#1

Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean. I want to know whether that ratio is bad, normal, or simply what happens.

If you are tracking this properly: same scanner, same time of day, same hydration, at least six months apart, and read grip strength or a lift number alongside it. Function is the outcome; the scan is the proxy.

What I am trying to establish is what fraction of loss being lean mass is actually normal, because the numbers quoted here range from 10% to 40% and cannot all be right.

Practical detail welcome, however dull — the duller the better.

4 24Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 1 other
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CarlaRPh_TPA
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Mar 15, 2026 at 10:25 AM#2

Taking the question as asked, rather than the general version of it. The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0 g/kg of reference body weight, and not making the deficit larger than the training can support. Cardio does not protect lean mass and in a deep deficit competes with recovery.

3 23ricardo_MIA, BrianDallas92, labquiet_amy
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laura_annarbor
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Mar 15, 2026 at 10:39 AM#3
CarlaRPh_TPA said:
The intervention that works is boring and well evidenced: resistance training two to three times a week at a genuine effort, protein at 1.4 to 2.0…

Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution. Hydration status moves the lean compartment by a kilogram or more between scans, so any comparison of scans done at different times of day or different hydration states is noise.

2 22Dr.SleepRoch, laura_annarbor
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mel_PDX
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Mar 15, 2026 at 10:53 AM#4
hyun_seoul said:
Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean.

Can confirm the pattern hyun_seoul describes. The honest range is roughly 20 to 40% of total loss as lean mass without deliberate resistance training, and roughly 10 to 20% with it plus adequate protein. Both numbers need a caveat that matters: "lean mass" on a DEXA is not muscle. It includes water, glycogen and the lean fraction of organs, and glycogen alone carries about three grams of water per gram. A large early lean drop is mostly the glycogen and water going, which is why the first scan flatters and the second is the honest one.

1 21BiostatsBrad
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sean_dublin
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Mar 15, 2026 at 12:07 PM#5

Clinical perspective, offered as context rather than as advice.

Back pain as a lean mass side effect: not from the medication itself, but from rapid body composition changes. Losing 66 lbs shifts your center of gravity and your core muscles need time to adjust.

Physical therapy has been essential. Core strengthening exercises (planks, dead bugs, bird dogs) daily for 10 minutes have eliminated my lower back pain. Your body is literally relearning how to carry itself.

Last edited: Mar 15, 2026 at 1:07 PM
50 20quinn_sf, NurseLeah_Nash, gary_naperville and 47 others
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