Acid reflux/GERD worsening on GLP-1 — November 2025

Dr.NutriCornell said:

Holding genuinely reduces total burden rather than redistributing it, because the gastric-emptying component adapts.

I dislike how confidently this board tells people to push through. Incidence figures around 20 to 25% at the higher doses are class-typical, but the trials also had a discontinuation column, and "manageable with protocols" is not the same as manageable for everyone.

Correct me if the detail matters more than I have assumed.

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

I would rather be corrected than agreed with, if it comes to it.

Dr.PainCLE said:

I dislike how confidently this board tells people to push through.

There is a second half to this that has not been said yet. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

One thing that is still open after Dr.LeslieOBGYN’s answer:

Whether holding at a lower dose for longer actually reduces total side-effect burden or just spreads it out?

OP back with an update, since a thread like this is useless without one.

Update. It was not the dose, it was that I had stopped drinking anything because drinking made me feel full. Fixing that fixed most of it.