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ForumsSide Effects & ManagementGallbladder disease risk — looking for input

Gallbladder disease risk — looking for input

PharmHunterJen Wed, Jun 12, 2024 at 12:32 PM 15 replies 2,145 viewsPage 1 of 3
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PharmHunterJen
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Jun 12, 2024 at 12:32 PM#1

Lost weight quickly, developed right-upper-quadrant pain after fatty meals, and ended up having an ultrasound that found what everybody had already guessed.

Symptoms worth knowing: right upper-quadrant pain after fatty meals, radiating to the right shoulder blade, often at night. That combination warrants imaging rather than a forum thread.

What would genuinely help is knowing how much of the gallbladder signal is the drug and how much is simply the rate of weight loss, because the answer changes what you can do about it.

I have searched first, so if this is covered somewhere point me at it and I will read it.

39 9Dr.LipidDallas, alex_tucson, kevin_tulsa and 36 others
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amsterdam_pete
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Jun 12, 2024 at 1:18 PM#2
PharmHunterJen said:
Lost weight quickly, developed right-upper-quadrant pain after fatty meals, and ended up having an ultrasound that found what everybody had already…

Gallbladder ultrasound monitoring on gallbladder risk: given the known gallstone risk with rapid weight loss, my doctor orders gallbladder ultrasound every 6 months:

Baseline: normal, no stones or sludge
Month 6: small amount of biliary sludge, no stones
Month 12: sludge resolved, gallbladder normal

Ursodeoxycholic acid (Ursodiol) 300mg BID was prescribed prophylactically from the start. This reduces gallstone formation during rapid weight loss by ~60% per the available data. Ask your doctor about prophylactic ursodiol if you're losing weight rapidly.

38 8ZaraB_AL, JakeSmashed95, NauseaFreeNow and 35 others
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anna.melb_AU
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Jun 12, 2024 at 2:04 PM#3
amsterdam_pete said:
Gallbladder ultrasound monitoring on gallbladder risk: given the known gallstone risk with rapid weight loss, my doctor orders gallbladder ultrasound…

Gallbladder warning for gallbladder risk: rapid weight loss increases gallstone risk regardless of method. GLP-1 patients have a ~2-3% incidence of gallbladder events in clinical trials.

Symptoms to watch for: pain in upper right abdomen after fatty meals, nausea after eating, pain radiating to right shoulder. I had my gallbladder out at month 8 — it was full of stones. My surgeon said it's very common in significant weight loss patients.

37 7emma_london, tammy_FL, Dr.LipidDallas and 34 others
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fiona_glasgow
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Jun 12, 2024 at 2:50 PM#4
PharmHunterJen said:
Lost weight quickly, developed right-upper-quadrant pain after fatty meals, and ended up having an ultrasound that found what everybody had already…

Same pattern here, and in the same order.

Last edited: Jun 12, 2024 at 7:50 PM
36 6JessicaH_TX, KevinCompounds, TirzTom and 33 others
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rachel_ABQ
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Jun 12, 2024 at 7:07 PM#5

Clinical perspective, offered as context rather than as advice. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

35 5Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 32 others
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