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ForumsMASH / Liver DiseaseSurvodutide SYNCHRONIZE Phase 3 — November 2025 Page 6

Survodutide SYNCHRONIZE Phase 3 — November 2025

ZaraB_AL Thu, Sep 12, 2024 at 4:18 AM 56 replies 2,243 viewsPage 6 of 12
lucas_SP_BR
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Nov 6, 2024 at 3:04 AM#26

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

40 13NurseKim_ATL, paul_denver, TinaHashiRN and 37 others
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Dr.LipidDallas
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Nov 13, 2024 at 4:01 AM#27

Following on from Dr.SportsMedIN — and this may be the naive question:

What would you measure differently if you were starting again?

41 14wei_SG, cory_ATX, lori_vegas and 38 others
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jim_asheville
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Nov 20, 2024 at 4:54 AM#28
lucas_SP_BR said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Pushing back on lucas_SP_BR here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

42 15NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 39 others
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MaxMetOK
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Nov 27, 2024 at 5:43 AM#29
lucas_SP_BR said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

43 16SleepFixSam, PurityPaulOR, MaxMetOK and 40 others
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ZaraB_AL
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Dec 4, 2024 at 6:28 AM#30

OP back with an update, since a thread like this is useless without one.

Update — my curve sits below the published mean and the explanation is that the trial arm had support I do not have. That was reassuring rather than otherwise.

Last edited: Dec 4, 2024 at 7:28 AM
15 13JennaRN, LabKate, kate.chem and 12 others
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