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ForumsProgress & Lab ResultsHas anyone dealt with insulin discontinued?

Has anyone dealt with insulin discontinued?

MikeFit_NJ Mon, Nov 10, 2025 at 11:01 PM 18 replies 1,254 viewsPage 1 of 4
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MikeFit_NJ
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Nov 10, 2025 at 11:01 PM#1

Read the primary source rather than the write-up and the two do not agree, so here is what is actually in it.

Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

Where I think it is weakest: the follow-up is short relative to how long people actually take these drugs, so durability is an assumption here rather than a finding.

What I actually want to know is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything. I have searched first, so if this is covered somewhere point me at it and I will read it.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
19 14LeilaHI, marcus_mpls, DeniseRN_TPA and 16 others
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FDA_TrackerJim
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Nov 10, 2025 at 11:44 PM#2
MikeFit_NJ said:
Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well…

Plateau breaking story with a stall: I stalled at 216 lbs for 5 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: switching from evening to morning injection. Lost 7 lbs in the next 2 weeks. Plateaus are temporary — they always break if you stay consistent.

Last edited: Nov 11, 2025 at 2:44 AM
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mike.trainer_LA
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Nov 11, 2025 at 12:27 AM#3
MikeFit_NJ said:
Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well…

This is where I part company with the consensus forming above. The "it is your intake" reflex here gets tiring. Some people genuinely stop responding at a dose that worked, and telling them to track harder when they have already tracked is how people stop posting.

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Dr.Martinez
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Nov 11, 2025 at 1:10 AM#4

Taking the question as asked, rather than the general version of it. Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body. A body 20kg lighter needs meaningfully fewer calories at rest and less to move, so the deficit that produced the first phase is arithmetically smaller now. The options are the honest ones — increase the deficit slightly, increase activity, or accept the new plateau — and escalating the dose is only one of them.

16 11Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 13 others
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DeniseRN_TPA
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Nov 11, 2025 at 5:13 AM#5
FDA_TrackerJim said:
Plateau breaking story with a stall: I stalled at 216 lbs for 5 weeks.

This matches mine closely enough to be worth saying so out loud. Posting only so the count is not one.

Last edited: Nov 11, 2025 at 8:13 AM
15 10Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 12 others
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