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ForumsMASH / Liver DiseaseSemaglutide and MASH — March 2026 Page 5

Semaglutide and MASH — March 2026

sophie_paris Tue, Dec 17, 2024 at 7:15 PM 42 replies 2,138 viewsPage 5 of 9
hank_denver
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Jan 17, 2025 at 8:10 AM#21

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

28 1ingrid_STO, pete_nash, hank_denver and 25 others
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Dr.EndoEP
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Jan 29, 2025 at 4:59 PM#22

A narrower follow-up, since the general answer is now clear:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

29 2james_edin, FranDenver, Dr.BariatricHTX and 26 others
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Dr.ObesityMed
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Feb 11, 2025 at 1:41 AM#23
hank_denver said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

30 3SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 27 others
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roxy_nash
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Feb 23, 2025 at 10:16 AM#24
hank_denver said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.

Last edited: Feb 23, 2025 at 4:16 PM
31 4Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 28 others
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adam_van
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Mar 7, 2025 at 6:44 PM#25
hank_denver said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

32 5hyun_seoul, jim_asheville, matt_MKE and 29 others
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