Can I drink on sema or will I die — need advice

NurseAsh_DET said:

Start from the measurement rather than the conclusion.

That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.

maya_sedona said:

Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

NurseAsh_DET said:

Start from the measurement rather than the conclusion.

This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.