From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
DataDave said:Say what you would expect to see if you were wrong, before you look.
Thank you for spelling out the reasoning rather than just the conclusion.
Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
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Browse GL BiochemDr.NateNeph said:The mechanism and the magnitude are separate questions.
All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.
Ask again with the specifics and you will get a better answer than this one.