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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseHas anyone dealt with fibrosis regression on glp-1? Page 6

Has anyone dealt with fibrosis regression on glp-1?

JenMemphis Sat, Apr 26, 2025 at 7:21 PM 46 replies 1,810 viewsPage 6 of 10
MarkLI_maint
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May 5, 2025 at 11:49 PM#26
wendy_avl said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

I read this differently from wendy_avl, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Correct me if the detail matters more than I have assumed.

Last edited: May 6, 2025 at 4:49 AM
44 17RunnerRach, TrialNerd_Beth, HPLC_Greg and 41 others
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tommy_boulder
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May 6, 2025 at 7:05 PM#27
wendy_avl said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

45 18TinaHashiRN, robert_kc, dan_philly and 42 others
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MounjBrad
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May 7, 2025 at 2:21 PM#28
wendy_avl said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Bookmarking. The distinction being drawn above is the one nobody else makes. Printing the relevant bit and taking it with me.

46 19nick_SD_fit, ben_calgary, patPC_UT and 43 others
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SarahChen_PharmD
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May 8, 2025 at 9:38 AM#29

From the other side of the consultation, briefly. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

47 20TinaHashiRN, robert_kc, dan_philly and 44 others
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JenMemphis
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May 9, 2025 at 4:55 AM#30

Reporting back.

Update, and it is the boring outcome: nothing was wrong. The measurement I was reading had moved less than its own week-to-week variation, which somebody said upthread and I did not believe.

Last edited: May 9, 2025 at 9:55 AM
19 17LarryQC_SD, wanda_boise, NurseAsh_DET and 16 others
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