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ForumsSide Effects & ManagementMood changes on GLP-1 — need advice Page 2

Mood changes on GLP-1 — need advice

NurseAsh_DET Mon, Dec 15, 2025 at 9:28 PM 28 replies 1,107 viewsPage 2 of 6
DebRD_ATL
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Feb 2024
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Dec 16, 2025 at 4:11 AM#6
Dr.GastroMayo said:
When to call your doctor about mental health side effects — a reference I wish I'd had: Call immediately: Severe abdominal pain (could be…

Pushing back on Dr.GastroMayo here. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

19 14BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 16 others
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quinn_sf
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Jun 2024
San Francisco, CA
Dec 16, 2025 at 6:49 AM#7
NurseAsh_DET said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Before/after narrative for mental health — one year in:

Before (266 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (191 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 96 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

Last edited: Dec 16, 2025 at 12:49 PM
18 13Dr.PathRoch, mona_PHX, andrew_nyc and 15 others
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DeniseRN_TPA
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Dec 16, 2025 at 9:27 AM#8
DebRD_ATL said:
I would be careful about how confidently the flatness reports get attributed.

Body image adjustment with mental health: I've lost 85 lbs but when I look in the mirror, I still see my old self sometimes. "Phantom fat" is a real phenomenon.

My therapist specializes in body image issues with weight loss patients. She says it can take 12-18 months for your brain's body map to update. In the meantime: take progress photos (your eyes lie but cameras don't), try on old clothes, and be patient with yourself.

17 12tommy_boulder, hyun_seoul, jim_asheville and 14 others
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greg_boulder
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Dec 16, 2025 at 12:05 PM#9

One thing that is still open after tammy_FL’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

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NurseAsh_DET
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Detroit, MI
Dec 17, 2025 at 12:44 AM#10

Reporting back.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.

Last edited: Dec 17, 2025 at 6:44 AM
30 3emily_PDX, Dr.SleepRoch, laura_annarbor and 27 others
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