CarlaRPh_TPA said:The liver data is among the strongest non-weight findings in the class.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
DoseLogDan said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.
CarlaRPh_TPA said:The liver data is among the strongest non-weight findings in the class.
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
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Shop Reference StandardsAdding the numbers, since they settle part of this. With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most threads assume.