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ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — anyone have experience? Page 4

Diarrhea vs constipation on GLP-1 — anyone have experience?

HPLC_Greg Sun, Jan 4, 2026 at 3:28 AM 21 replies 1,190 viewsPage 4 of 5
DoseLogDan
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Jan 21, 2026 at 12:53 AM#16
carl_compliance said:
Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for…

Second this. Posting only so the count is not one.

11 9newstart_MO, mia_MS2, LeilaHI and 8 others
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SarahChen_PharmD
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Jan 23, 2026 at 2:48 PM#17
Dr.RaviCardio said:
Gastric emptying studies and constipation: semaglutide delays gastric emptying by ~40% at steady state, as measured by acetaminophen absorption…

Adding the part of the answer the thread has not reached. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Last edited: Jan 23, 2026 at 5:48 PM
12 10NurseKim_ATL, paul_denver, TinaHashiRN and 9 others
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quinn_sf
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Jan 26, 2026 at 4:42 AM#18

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

That is the short version; the long version is somebody else's post.

13 11mona_PHX, andrew_nyc, Dr.EndoEP and 10 others
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rachel_ABQ
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Jan 28, 2026 at 6:34 PM#19

One thing that is still open after Dr.RaviCardio’s answer:

How long did you give it before you decided it was working?

14 12SkepticalSean, Dr.CardioMD, EndoResFellow and 11 others
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Admin
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Jan 31, 2026 at 8:25 AM#20

Moderator note: a couple of off-topic posts removed. Carry on.

36 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 33 others
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