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ForumsSide Effects & ManagementTMI but the constipation is REAL Page 8

TMI but the constipation is REAL

NauseaFreeNow Fri, Apr 17, 2026 at 1:00 PM 37 replies 1,223 viewsPage 8 of 8
JenPlateau
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Apr 23, 2026 at 12:11 PM#36

From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Ask again with the specifics and you will get a better answer than this one.

32 5HPLC_Greg, LibrarianMeg, bri_stats and 29 others
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HPLC_Greg
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Apr 23, 2026 at 7:07 PM#37
JenPlateau said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Second this. I had assumed I was the exception until I read this.

Last edited: Apr 24, 2026 at 1:07 AM
33 6JenPlateau, SallyK_inj, CryptoCarl and 30 others
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pete_manc_UK
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Apr 24, 2026 at 2:03 AM#38
JenPlateau said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Adding the part of the answer the thread has not reached. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

34 7FitDadDave, RunnerRach, TrialNerd_Beth and 31 others
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PharmacoVig_BOS
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Apr 24, 2026 at 8:58 AM#39

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

I would rather be corrected than agreed with, if it comes to it.

35 8kate.chem, DataDave, Dr.GutHealth and 32 others
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TrialNerd_Beth
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Apr 24, 2026 at 3:53 PM#40

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

7 5SleepFixSam, PurityPaulOR, MaxMetOK and 4 others
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