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ForumsMASH / Liver DiseaseWhat even is MASH? My doc mentioned it and I panicked — looking for input Page 3

What even is MASH? My doc mentioned it and I panicked — looking for input

BiostatsBrad Wed, Feb 18, 2026 at 2:00 PM 24 replies 1,348 viewsPage 3 of 5
dave_SLC
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Feb 19, 2026 at 8:05 AM#11
BariatricNurseD said:
Liver enzyme update related to liver and MASH: I had mildly elevated ALT/AST at baseline (likely NAFLD).

Bookmarking. The distinction being drawn above is the one nobody else makes. Printing the relevant bit and taking it with me.

Last edited: Feb 19, 2026 at 12:05 PM
31 4mike_mealprep, NicoleRaleigh, james_edin and 28 others
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DeniseRN_TPA
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Tampa, FL
Feb 19, 2026 at 3:27 PM#12

Clinical perspective, offered as context rather than as advice. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

32 5hyun_seoul, jim_asheville, matt_MKE and 29 others
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Dr.KarenChen
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Feb 19, 2026 at 10:49 PM#13
Dr.GutHealth said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

Pushing back on Dr.GutHealth here. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

33 6TomFromTexas, mike.trainer_LA, sarah_nash92 and 30 others
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dan_philly
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Feb 20, 2026 at 6:11 AM#14

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

34 7Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 31 others
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Admin
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Feb 20, 2026 at 1:34 PM#15

Moderator note: a couple of off-topic posts removed. No action needed from anybody.

35 8PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 32 others
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